- Chemical Name: 3-BENZYL-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-ETHYL ESTER
- CAS No.: 170842-80-5
Good factory supply good 3-BENZYL-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-ETHYL ESTER 170842-80-5
- Molecular Formula: C20H29NO4
- Molecular Weight: 347.455
- Boiling Point: 431.8±38.0 °C(Predicted)
- PKA: -2.40±0.40(Predicted)
- PSA： 55.84000
- Density: 1.101±0.06 g/cm3(Predicted)
- LogP: 3.74740
170842-80-5 Relevant articles
Heterocycyclic piperidines as modulators of chemokine receptor activity
-
, (2008/06/13)
The present application describes modula...
Compound with growth hormone releasing properties
-
, (2008/06/13)
The present invention describes a new co...
Process for the preparation of (S)-3-carbethoxy-3-benzylpiperidine
-
, (2008/06/13)
The present invention is concerned with ...
1-[2(R)-(2-amino-2-methylpropionyl-amino)-3-(1H-indol-3-yl)propionyl]- 3-benzylpiperidine-3(S)-carboxylic acid ethyl ester (L-163,540): A potent, orally bioavailable, and short-duration growth hormone secretagogue [1]
Yang, Lihu,Morriello, Greg,Patchett, Arthur A.,Leung, Kwan,Jacks, Tom,Cheng, Kang,Schleim, Klaus D.,Feeney, William,Chan, Wanda W.-S.,Chiu, Shuet-Hing L.,Smith, Roy G.
, p. 2439 - 2441 (2007/10/03)
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170842-80-5 Process route
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-
148672-74-6,130250-54-3
ethyl N-(t-butyloxycarbonyl)nipecotate
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-
100-39-0
benzyl bromide
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-
170842-80-5
3-Benzylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
| Conditions | Yield |
|---|---|
|
With
lithium hexamethyldisilazane;
Multistep reaction;
1.) THF, -78 deg C, 2.) THF, from -78 deg C to 0 deg C;
|
|
|
With
hydrogenchloride; sodium hexamethyldisilazane;
In
tetrahydrofuran; ethyl acetate; toluene;
|
-
(42/58) MeCN
-
(42/58) MeCN
-
(42/58→62/38) MeCN
-
(42/58→62/38) MeCN
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(62/38) MeCN
-
(62/38) MeCN
-
-
S-3-Carbethoxy-3-benzyl-2-hydroxy-N-Boc-piperidine
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-
86119-84-8,7664-38-2
phosphoric acid
-
-
7637-07-2
boron trifluoride
-
-
121893-20-7
tert-butyl nitrosoformate
-
-
170842-80-5
3-Benzylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
| Conditions | Yield |
|---|---|
|
With
triethylsilane; trifluoroborane diethyl ether;
In
dichloromethane;
|
170842-80-5 Upstream products
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148672-74-6
ethyl N-(t-butyloxycarbonyl)nipecotate
-
100-39-0
benzyl bromide
-
24424-99-5
di-tert -butyl dicarbonate
-
71962-74-8
Ethyl nipecotate
170842-80-5 Downstream products
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170844-89-0
3-Benzyl-piperidine-3-carboxylic acid ethyl ester
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170844-45-8
(S)-3-carbethoxy-3-benzylpiperidine
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170844-47-0
(S)-3-Benzyl-1-[(R)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-piperidine-3-carboxylic acid ethyl ester
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170842-83-8
(S)-3-Benzyl-1-[(R)-2-(2-tert-butoxycarbonylamino-2-methyl-propionylamino)-3-(1H-indol-3-yl)-propionyl]-piperidine-3-carboxylic acid ethyl ester