Home >Pharmaceutical > 2-Bromo-4,5-dimethoxybenzyl bromide
- Chemical Name: 2-Bromo-4,5-dimethoxybenzyl bromide
- CAS No.: 53207-00-4
2-Bromo-4,5-dimethoxybenzyl bromide 53207-00-4 with purity >99% Low price in stock
- Molecular Formula: C9H10Br2O2
- Molecular Weight: 309.985
- Vapor Pressure: 0.001mmHg at 25°C
- Melting Point: 84.0-85.5 °C
- Refractive Index: 1.568
- Boiling Point: 320.637 °C at 760 mmHg
- Flash Point: 129.614 °C
- PSA： 18.46000
- Density: 1.693g/cm3
- LogP: 3.36120
2-Bromo-4,5-dimethoxybenzyl bromide(Cas 53207-00-4) Usage
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General Description |
2-Bromo-4,5-dimethoxybenzyl bromide is a chemical compound with the molecular formula C9H10Br2O2. It is a white to off-white crystalline solid that is primarily used as an intermediate in the synthesis of pharmaceuticals and organic compounds. 2-Bromo-4,5-dimethoxybenzyl bromide is a brominated derivative of 4,5-dimethoxybenzyl bromide, and its distinctive structure makes it useful for a variety of chemical reactions, including nucleophilic substitution and carbon-carbon coupling reactions. It is important to handle this compound with care, as it is toxic and can cause irritation to the skin, eyes, and respiratory system upon contact or inhalation. |
InChI:InChI=1/C9H10Br2O2/c1-12-8-3-6(5-10)7(11)4-9(8)13-2/h3-4H,5H2,1-2H3
53207-00-4 Relevant articles
Pd-catalyzed sp-sp3cross-coupling of benzyl bromides using lithium acetylides
Buter, Jeffrey,Doze, Anna M.,Feringa, Ben L.,Mondal, Anirban,Visser, Paco
supporting information, p. 7529 - 7532 (2021/08/05)
Organolithium-based cross-coupling react...
Formal total synthesis of salvianolic acid N
Wu, Kong,Xie, Zhong Pao,Cui, Dong-Mei,Zhang, Chen
, p. 832 - 837 (2018/02/09)
An efficient synthetic pathway for the t...
Synthetic Utility of Arylmethylsulfones: Annulative π-Extension of Aromatics and Hetero-aromatics Involving Pd(0)-Catalyzed Heck Coupling Reactions
Sankar, Elumalai,Raju, Potharaju,Karunakaran, Jayachandran,Mohanakrishnan, Arasambattu K.
, p. 13583 - 13593 (2017/12/26)
A straightforward and general method for...
Preparation method for pinaverium bromide intermediate 2-bromo-4,5-dimethoxybenzyl bromide
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Paragraph 0052; 0053; 0054; 0055; 0056; 0057; 0058-0071, (2018/03/01)
The invention provides a preparation met...
53207-00-4 Process route
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54370-00-2
2-bromo-4,5-dimethoxybenzyl alcohol
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53207-00-4
1-bromo-2-(bromomethyl)-4,5-dimethoxybenzene
| Conditions | Yield |
|---|---|
|
With
pyridine; phosphorus tribromide;
In
chloroform;
at 0 - 20 ℃;
|
81%
|
|
With
carbon tetrabromide; triphenylphosphine;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 20h;
|
39%
|
|
With
phosphorus tribromide;
|
|
|
With
N-Bromosuccinimide; triphenylphosphine;
|
|
|
With
phosphorus tribromide;
In
diethyl ether;
at 0 - 23 ℃;
for 0.833333h;
Inert atmosphere;
|
|
|
With
phosphorus tribromide;
In
dichloromethane;
at 0 ℃;
for 0.5h;
|
|
|
With
phosphorus tribromide;
In
dichloromethane;
at 0 - 5 ℃;
for 0.75h;
|
|
|
With
pyridine; phosphorus tribromide;
In
dichloromethane;
at 0 - 20 ℃;
for 1h;
Inert atmosphere;
|
|
|
With
phosphorus tribromide;
In
dichloromethane;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
|
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494-99-5
1,2-dimethoxy-4-methylbenzene
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53207-00-4
1-bromo-2-(bromomethyl)-4,5-dimethoxybenzene
| Conditions | Yield |
|---|---|
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1,2-dimethoxy-4-methylbenzene;
With
sodium bromate; sodium bromide;
In
tetrachloromethane;
Reflux;
With
sulfuric acid;
In
tetrachloromethane; water;
for 2.5h;
With
2,2'-azobis-(2,4-dimethylvaleronitrile); sulfuric acid;
In
tetrachloromethane; water;
for 6h;
Reflux;
|
85%
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53207-00-4 Upstream products
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93-03-8
(3,4-dimethoxyphenyl)methanol
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54370-00-2
2-bromo-4,5-dimethoxybenzyl alcohol
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5392-10-9
2-bromo-4,5-dimethoxybenzaldehyde
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120-14-9
3,4-dimethoxy-benzaldehyde
53207-00-4 Downstream products
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53251-94-8
Pinaverium bromide
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83392-72-7
(2-bromo-4,5-dimethoxybenzyl)trimethylsilane
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106544-58-5
(4,5-dimethoxy-2-(trimethylsilyl)benzyl)trimethylsilane
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54712-52-6
6'-bromolaudanosine