- Chemical Name: Sparsomycin
- CAS No.: 1404-64-4
Quality products?make an important contribution to long-term revenue and profitability. Chemical plants supply high-quality Sparsomycin 1404-64-4 in bulk
1.What is the Sparsomycin ?
Sparsomycin is an antibiotic that binds to active site and exit tunnel hydrophobic crevices of peptidyltransferase center of Haloarcula marismortui large ribosomal subunit.
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95407-15-1
O-(methoxymethyl)sparsomycin
-
-
1404-64-4
sparsomycin
| Conditions | Yield |
|---|---|
|
With
Dowex(R) 50W H(1+) form;
In
methanol;
at 50 ℃;
for 2h;
|
74%
|
|
With
methanol; Dowex 50W;
at 50 ℃;
|
73%
|
|
With
hydrogenchloride;
In
methanol;
at 50 ℃;
for 5h;
|
65%
|
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-
95407-13-9
(RS )-O-(methoxymethyl)-S-((methylthio)methyl)-D-cysteinol S-oxide
-
-
1404-64-4
sparsomycin
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
2
steps
1: 88 percent / dicyclohexyl carbodiimide; 1-hydroxy-7-azabenzotriazole / dimethylformamide / 12 h / 20 °C
2: 74 percent / Dowex(R) 50W H(1+)
form / methanol / 2 h / 50 °C
With
1-hydroxy-7-aza-benzotriazole; Dowex(R) 50W H(1+) form; dicyclohexyl-carbodiimide;
In
methanol; N,N-dimethyl-formamide;
|
|
|
Multi-step reaction
with
2
steps
1: 38 percent / 1,3-dicyclohexylcarbodiimide, 1-hydroxybenzo-7-azatriazole / tetrahydrofuran; dimethylformamide / Ambient temperature
2: 73 percent / Dowex 50W, MeOH / 50 °C
With
methanol; 1-hydroxy-7-aza-benzotriazole; Dowex 50W; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
|
|
|
Multi-step reaction
with
2
steps
1: tetrahydrofuran; dimethylformamide / 36 h / Ambient temperature
2: 65 percent / 1 N HCl / methanol / 5 h / 50 °C
With
hydrogenchloride;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
|
2.What is the CAS number for Sparsomycin ?
The CAS number of Sparsomycin is 1404-64-4.
More information of Sparsomycin 1404-64-4 are:
|
CAS?Number |
1404-64-4 |
|
Density |
1.466 g/cm3 |
|
Melting Point |
208-209° (dec) |
|
Refractive Index |
1.6390 (estimate) |
|
PSA |
176.63000 |
|
LogP |
0.18770 |
|
Pka |
8.67 in water, 9.05 in 40% ethanol |
3.What are another words for Sparsomycin ?
Synonyms?for?Sparsomycin 1404-64-4:2-Propenamide,N-[1-(hydroxymethyl)-2-[[(methylthio)methyl]sulfinyl]ethyl]-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)-,[R-[R*,S*-(E)]]-;5-Pyrimidineacrylamide,1,2,3,4-tetrahydro-N-[1-(hydroxymethyl)-2-[[(methylthio)methyl]sulfinyl]ethyl]-6-methyl-2,4-dioxo-,(E)-(1S)- (8CI);Sparsomycin (7CI);(+)-Sparsomycin;NSC 059729;NSC 59729;U19183;
4.What is the molecular formula of Sparsomycin?
The chemical formula of ?Sparsomycin is?C13H19N3O5S2 which containing 13 Carbon atoms,19 Hydrogen atoms,3 Nitrogen atoms,5 Oxygen atoms and 2 Sulfur atoms,and the molecular weight of??Sparsomycin?is 361.443.
5.What is Sparsomycin (1404-64-4) used for?
Sparsomycin is a bacterial metabolite and a nucleoside analog of uracil that has been found in S. sparsogenes and has diverse biological activities. It is active against KB carcinoma cells, Gram-positive and Gram-negative bacteria, and fungi. Sparsomycin is an inhibitor of peptidyl transferase that interferes with tRNA binding to the A-site of the peptidyl transfer center and increases the binding of peptidyl-tRNA to the P-site. It inhibits protein synthesis in bacteria, archaea, and eukaryotes. Sparsomycin reduces tumor growth in a P388 mouse leukemia model and in a Walker 256 carcinosarcoma rat model.
InChI:InChI=1/C13H19N3O5S2/c1-8-10(12(19)16-13(20)14-8)3-4-11(18)15-9(5-17)6-23(21)7-22-2/h3-4,9,17H,5-7H2,1-2H3,(H,15,18)(H2,14,16,19,20)/b4-3+
Relevant articles related to Sparsomycin:
|
Article |
Source |
|
Synthesis and morphological reversion activity on src(ts)NRK cells of pyrimidinylpropanamide antibiotics, sparsomycin, sparoxomycin A1, A2, and their analogues |
Nakajima, Noriyuki,Enomoto, Takeshi,Matsuura, Nobuyasu,Ubukata, Makoto , p. 3331 - 3334 (2007/10/03) |
|
Total synthesis of (+)-sparsomycin. Approaches using cysteine and serine inversion |
Hwang,Helquist,Shekhani , p. 1264 - 1271 (2007/10/02) |
6.Buy Sparsomycin with the best price .
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